1. Optical coherence tomography angiography for noninvasive evaluation of angiogenesis in a limb ischemia mouse model

    Optical coherence tomography angiography for noninvasive evaluation of angiogenesis in a limb ischemia mouse model

    We developed an optical coherence tomography angiography technique by improving the speckle contrast algorithm and the imaging process. This technique, which can achieve angiogenesis imaging in vivo without increasing trauma, was used to evaluate the microvasculature in limb ischemia mice. Sixteen left hindlimb ischemia mice were randomly allocated into CuSO 4 and saline groups. Within 7 days after treatment, limb ischemic damage, temperature and histological staining were assessed by traditional methods. In addition, angiogenesis was evaluated using an optical coherence tomography angiography system in vivo . All results were compared. After 7 days of treatment, both the ischemic tissue damage score ...

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