1. Comparing the Risk Factors of Plaque Rupture and Failed Plaque Healing in Acute Coronary Syndrome

    Comparing the Risk Factors of Plaque Rupture and Failed Plaque Healing in Acute Coronary Syndrome

    The article by Vergallo et al 1 in this issue of JAMA Cardiology supports a hypothesis that healed plaques are a marker for reduced acute coronary syndrome (ACS) risk. This commentary expands on this idea by examining a mechanistic hypothesis of their results beyond looking at healing just as a marker. Specifically, failed healing, which correlated in the study by Vergallo et al 1 with long core axial extent, predisposes plaque ruptures to progress to ACS. Acute coronary syndrome may require a double hit of both rupture and impaired healing. This is somewhat analogous to the situation in oncology, where ...

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