1. Screening for esophageal cancer and Barrett’s esophagus

    Abstract  The incidence of esophageal adenocarcinoma is rapidly increasing. Because endoscopically recognizing the associated premalignant condition (Barrett’s esophagus) is feasible, many have recommended endoscopic screening and surveillance to decrease mortality from this cancer. However, such a strategy remains controversial, because it is impaired by poor ability to select high-risk patients for screening, limited ability to stratify patients on the risk of progression to cancer, and unproven efficacy for reducing mortality. This review summarizes the published guideline recommendations for screening and surveillance for esophageal adenocarcinoma, the limitations of such a strategy, and emerging progress toward a more rational, effective strategy ...
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