1. Identification of optical density ratios in subretinal fluid as a clinically relevant biomarker in exudative macular disease

    Purpose: To investigate the potential role of optical density ratios (ODR) obtained from subretinal fluid analysis in exudative macular disease and to identify the predictive role of ODR under therapy in comparison to conventional morphometric measurements (CMM). Methods: Fifteen patients with neovascular age-related macular degeneration (nAMD) and 15 patients with acute central serous chorioretinopathy (CSC) were included into this prospective comparative and interventional case series. High-definition optical coherence tomography (SD-OCT) was performed according to a standardized protocol. NAMD patients received a standard treatment consisting of 3 monthly doses of intravitreal ranibizumab. Best-corrected visual acuity (BCVA) was assessed at baseline, week ...
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