1. Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

    Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

    Introduction Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA‐cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non‐invasively visualize GMPs and describe photothermal tissue effects. Objectives To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser‐mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Methods Patients with facial acne ( n  = 14), and healthy participants ( n  = 7) were included. RCM and OCT images were acquired at baseline, after GMP application, and ...

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