1. Intimal lesions detected by optical coherence tomography herald intraluminal progression of cardiac allograft vasculopathy associated with humoral rejection

    Intimal lesions detected by optical coherence tomography herald intraluminal progression of cardiac allograft vasculopathy associated with humoral rejection

    This case illustrates humoral-rejection related cardiac graft vasculopathy (CAV) in a 44-year-old heart transplant recipient. In March 2018, at 3 years post-transplant de novo anti-HLA Class II donor-specific antibodies (DSA: DQ2 + DQ7 >25 000 MFI) were detected. The coronary angiogram (CA) in 2016 had been unsuspicious ( Panels A and B ; left), whereas optical coherence tomography (OCT) had noted a pathologic intima: media thickness ratio of 2:1 ( Panel C , left). The CA in March 2018, however, showed mild Type C CAV lesions in the distal LAD and RCA ( Panels A and B ; middle). Moreover, OCT marked intimal ‘opacity’ ( Panel C ,...

    Read Full Article

    Login to comment.

  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics Mentioned

  3. Authors