1. Multimodal Retinal Imaging of the Angiofibrotic Switch in Neovascular AMD

    Multimodal Retinal Imaging of the Angiofibrotic Switch in Neovascular AMD

    The content of this research project is to identify the angiofibrotic switch, the transition from angiogenesis to fibrosis, in neovascular age-related macular degeneration (nAMD) longitudinally. AMD is the most important cause of vision loss of the elderly in industrialized countries. Despite optimal treatment about 50% of eyes with nAMD develop fibrosis within 2 years, causing irreversible damage to the retina and functional loss. Objective measurement of fibrosis, however, is challenging, since clinical staging is subjective and current imaging modalities such as color fundus photography (CFP), fluorescein angiography (FA) and optical coherence tomography (OCT) often do not allow clear delineation. Novel ...

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