1. Development of cellular resolution optical coherence tomography (Thesis)

    Development of cellular resolution optical coherence tomography (Thesis)

    Diagnosis of most mucosal diseases including epithelial cancers relies on white-light endoscopy/visual inspection followed by random biopsy and histologic examination. These current standard-of-care tools are associated with many issues such as sampling errors, tissue destruction, and processing artifacts. In addition, it is too traumatic to take a biopsy from tissues like eyes and coronary arteries. Being high resolution, high speed, and non-invasive, optical coherence tomography (OCT) has emerged as an endoscopic and intravascular imaging tool that provides valuable anatomic information complementary to the standard-of-care techniques. However, it has a typical resolution of 10 μm, which is too coarse to ...

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