1. Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography

    Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography

    Purpose To assess depth-dependent corneal displacements in live normal subjects using optical coherence elastography (OCE). Methods A corneal elastography method based on swept-source optical coherence tomography (OCT) was implemented in a clinical prototype. Low amplitude corneal deformation was produced during OCT imaging with a linear actuator-driven lens coupled to force transducers. A cross-correlation algorithm was applied to track frame-by-frame speckle displacement across horizontal meridian scans. Intra-measurement force and displacement data series were plotted against each other to produce local axial stiffness approximations, k , defined by the slope of a linear fit to the force/displacement data (ignoring non-axial contributions from ...

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