1. Small HDL Subclass is Associated with Coronary Plaque Stability: An Optical Coherence Tomography Study in Patients with Coronary Artery Disease

    Small HDL Subclass is Associated with Coronary Plaque Stability: An Optical Coherence Tomography Study in Patients with Coronary Artery Disease

    Background The role of high-density lipoprotein (HDL) subclasses in atherosclerotic diseases remains an open question. Previous clinical trials have attempted to explore the predictive effect of HDL subspecies on cardiovascular risk. However, no studies have assessed the connections between these subclasses and characteristics of plaque microstructure. Objective To investigate the relationship of HDL subclasses and coronary plaque stability assessed by optical coherence tomography (OCT). Methods Morphological characteristics of 160 non-target lesions from 85 patients with coronary artery disease were assessed by OCT. High-density lipoprotein (HDL) subclass profiles were analyzed using non-denaturing polyacrylamide gel electrophoresis. Results The plasma levels of small ...

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