1. Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model

    Purpose. To evaluate the functional outcome of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier and transplanted in the living feline model. Methods. Eighteen healthy adult cats underwent full thickness corneal transplantation. In 11 animals, the donor cornea was reconstructed from cultured allogeneic feline corneal endothelial cells seeded on the denuded Descemet’s membrane of a devitalized human cornea. The reconstructed corneal endothelium was cultured for two weeks before transplantation. Five control animals received either an autologous (n=1), an allogeneic (n=3) or a human xenogeneic (n=1) native cornea. Two other control animals were grafted with the ...
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