1. Assessment of microvasculature flow state with a high speed all-optic dual-modal system of optical coherence tomography and photoacoustic imaging

    Assessment of microvasculature flow state with a high speed all-optic dual-modal system of optical coherence tomography and photoacoustic imaging

    We propose a high speed all-optic dual-modal system that combines spectral domain optical coherence tomography (SDOCT) and photoacoustic imaging (PAI) to evaluate microvasculature flow states. A homodyne interferometer was used to remotely detect the surface vibration caused by photoacoustic (PA) waves. The PA excitation, PA probing and SDOCT probing beams share the same X-Y galvanometer scanner to perform fast two-dimensional scanning. In addition, we introduced multi-excitation, dual-channel acquisition and sensitivity compensation to improve the imaging speed of the PAI sub-system. The total time for imaging a sample with 256 × 256 pixels is less than 1 minute. The performance of the ...

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