1. Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Different Clinical Subtypes of Multiple Sclerosis

    Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Different Clinical Subtypes of Multiple Sclerosis

    Background Multiple sclerosis (MS) is a chronic inflammatory demyelinating autoimmune disease of the central nervous system (CNS) with axonal degeneration as major determinant of neurological disability. Assessment of unmyelinated retinal nerve fibers using optical coherence tomography (OCT) may be useful for diagnosing the onset and rate of progression of neurodegeneration. Objective To assess the incidence and severity of damage of the peripapillary retinal nerve fiber layer (RNFL) in two different MS subtypes: non-progressive [Prog(-)MS] and progressive [Prog(+)MS]. Methods 48 patients (96 eyes) with MS were included: 13 males, 35 females; aged 22-62 years (mean 38.8; SD ±10 ...

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