1. Numerical Investigation of Atherosclerotic Plaque Rupture using Optical Coherence Tomography Imaging and XFEM

    Numerical Investigation of Atherosclerotic Plaque Rupture using Optical Coherence Tomography Imaging and XFEM

    Myocardial infarction contributes to most fatalities in which atherosclerotic plaque disruption is the underlying pathology. From the mechanics view point, the pulsatile blood flow in the arteries resembles a fatigue environment and generates stresses that affect the rupture of the atherosclerotic plaque. In this context, patient-specific optical coherence tomography (OCT) was used to develop the fatigue crack growth behavior. The impact of location specific morphological features and their relative effect on plaque life were discussed. EXtended Finite Element Method (XFEM) and Paris’ Law were employed to investigate the fatigue crack growth. Twelve 2D slices from six patients were reconstructed for ...

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