1. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

    Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

    It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with dynamic and static ventilation protocols. Validation of dynamic aOCT luminal cross-sectional area (CSA) measurements against Cine CT, obtained during the same exam, showed an aggregate difference of 15  %    ±  3  %  . aOCT-derived ...

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