1. Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

    Quantitative Articular Cartilage Sub-Surface Defect Assessment Using Optical Coherence Tomography: An In-Vitro Study

    Assessment of structural cartilage damage is of high scientific and clinical interest. Optical Coherence Tomography (OCT) is a light-based cross-sectional imaging modality that allows the real-time assessment of articular cartilage at near-histological resolution. Algorithm routines for the detection, parameterization and quantification of sub-surface defects as assessed by OCT were implemented and validated in this study. Standard defects of 0.9 mm, 1.1 mm and 1.3 mm diameter were created in the sub-surface regions of macroscopically intact human articular cartilage samples (n = 60 defects of variable sizes in n = 20 samples). Subsequently, samples were scanned by 3D OCT and ...

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