1. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

    The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

    Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement is fundamental for tumor growth, worsening the prognosis. Dynamic Optical Coherence Tomography (D‐OCT) enables the in vivo evaluation of vascular patterns in skin lesions. Objective In vivo evaluation of the melanoma vessel morphology by means of D‐OCT and correlation with Breslow index. Methods Retrospective analysis of histologically proven melanomas, evaluated by D‐OCT at three different depths (150, 300 and 500 μm) was performed. Vessels were classified according to morphology (dots, blobs, coiled, line, curved, serpiginous), distribution (regular, irregular), and presence/type ...

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