1. Imaging of Coronary Plaques in Subjects Treated With Evolocumab

    Imaging of Coronary Plaques in Subjects Treated With Evolocumab

    This study seeks to identify morphologic changes, such as increase in fibrous cap thickness (FCT), in atherosclerotic plaques associated with treatment with evolocumab and maximally tolerated statin therapy with or without additional lipid-modifying medication in patients presenting with non-ST-segment elevation (NSTE)-ACS using optical coherence tomography (OCT;primary, secondary, and exploratory endpoints) and intravascular ultrasound (IVUS; exploratory endpoints only)

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