1. Measurement of Flow‐Mediated Dilation of Mouse Femoral Artery in vivo by Optical Coherence Tomography

    Measurement of Flow‐Mediated Dilation of Mouse Femoral Artery in vivo by Optical Coherence Tomography

    Flow‐mediated vasodilation (FMD) is used for assessment of vascular endothelial function in humans as a predictor of cardiovascular events. It has been challenging to carry it on preclinical murine models due to the diminutive size of the femoral artery. Here, we present a new approach to accurately measure the blood velocity and femoral artery diameters of mice by acquiring Doppler optical coherence tomography (DOCT) and optical coherence tomography angiography (OCTA) continuously within one single experimental scanning protocol. Using the high precision three‐dimensional imaging and new velocity algorithm, the measurement precision of diameter, blood flow, velocity, and wall shear ...

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