1. Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

    Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

    Objective: A novel hearing-aid scheme using magnetomotive nanoparticles (MNPs) as transducers in the tympanic membrane (TM) is proposed, aiming to noninvasively and directly induce a modulated vibration on the TM. Methods: In this feasibility study, iron-oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles were applied on ex vivo rat TM tissues and allowed to diffuse over ~2 hr. Subsequently, magnetic force was exerted on the MNP-laden TM via a programmable electromagnetic solenoid to induce the magnetomotion. Optical coherence tomography (OCT), along with its phase-sensitive measurement capabilities, was utilized to visualize and quantify the nanometer-scale vibrations generated on the ...

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