Feature Of The Week 04.05.2018: Fiber-Coupled Multimodal Imaging for Non-Destructive Assessment of Vascular Biomaterials
We present a novel fiber-based imaging platform that allows simultaneous fluorescence lifetime imaging (FLIm) and optical coherence tomography (OCT) using a double-clad fiber. This platform acquires co-registered images showing structural and compositional contrast in unlabeled biological samples by scanning the fiber tip across the sample surface. In this Letter, we report a characterization of each modality and show examples of co-registered FLIm and OCT images acquired from a lemon segment and a section of human coronary artery. The close comparison between the combined FLIm and OCT images and a co-registered histology section provides a qualitative validation of the technique and highlights its potential for minimally invasive, multimodal imaging of tissue structure and composition.
For more information see recent Article. Courtesy Benjamin E. Sherlock from Courtesy University of California, Davis. To share this article click Here.