1. Contrast enhancement of microscopic birefringent crystals using polarization sensitive micro-optical coherence tomography

    Contrast enhancement of microscopic birefringent crystals using polarization sensitive micro-optical coherence tomography

    Background: Birefringent crystals such as cholesterol and monosodium urate have recently been identified as possible pharmacologic targets for the treatment of coronary artery disease. The size of these crystals can be very small (on the order of 1 µm), making them difficult to identify. To image these microscopic crystals and enhance contrast, we modified existing micro optical coherence tomography system so that it was capable of obtaining polarization-sensitive images (PS-µOCT). A spectrometer-based PS-µOCT system was developed using a 270 nm wide broadband light source centered at 765 nm. Light was polarized using a polarizer and coupled to a ...

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