1. Impact of Ticagrelor and Aspirin versus Clopidogrel and Aspirin in Symptomatic Patients with Peripheral Arterial Disease: Thrombus Burden Assessed by Optical Coherence Tomography

    Impact of Ticagrelor and Aspirin versus Clopidogrel and Aspirin in Symptomatic Patients with Peripheral Arterial Disease: Thrombus Burden Assessed by Optical Coherence Tomography

    Purpose To compare OCT identified white thrombus decline, neointimal hyperplasia and clinical outcomes of patients treated with ticagrelor plus aspirin with those patients treated with clopidogrel plus aspirin after peripheral interventions. Background Ticagrelor is a potent platelet inhibitor. In patients with coronary artery disease, ticagrelor and aspirin demonstrated reduced rates of stent thrombosis, compared to aspirin and clopidogrel. The clinical importance of potent antiplatelet inhibition after peripheral endovascular interventions is unknown. Methods We enrolled 18 patients with superficial femoral artery disease and the presence of OCT-detected clot post-stent placement. Patients were randomized to 75 mg clopidogrel once daily for 1 ...

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