1. Predictors of Retinal Atrophy in Multiple Sclerosis: A Longitudinal Study Using Spectral Domain Optical Coherence Tomography with Segmentation Analysis

    Predictors of Retinal Atrophy in Multiple Sclerosis: A Longitudinal Study Using Spectral Domain Optical Coherence Tomography with Segmentation Analysis

    Background Multiple sclerosis is an inflammatory demyelinating disease characterized by progressive axonal loss affecting mainly the inner retinal layers. Optical coherence tomography (OCT) provides in-vivo quantification of the retinal layers and allows measuring progressive retinal changes. Our objective was to assess the longitudinal changes in the retina using spectral domain OCT (SDOCT) and to identify independent predictors affecting retinal thinning in MS patients. Methods A prospective study in a tertiary care MS center was conducted to study the longitudinal retinal changes in MS patients. All subjects underwent baseline and follow up OCT assessment with segmentation analysis. Regression analysis was performed ...

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