1. Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography

    Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography

    Purpose: To quantify retinal microvasculature within the macular ganglion cell-inner plexiform layer (GCIPL) in primary open angle glaucoma (POAG) and normal eyes, determine association of vessel parameters with structural and functional measures, and report diagnostic accuracy of vessel parameters. Methods: POAG and normal patients underwent 6▒mm×6▒mm macula scans (Angioplex TM optical coherence tomography angiography [OCTA]; Cirrus TM HD-OCT 5000); and Humphrey Field Analyzer II-i 24-2 visual field (VF) (Zeiss, Dublin, CA). Prototype software performed semi-automatic segmentation to create GCIPL en face images, and quantified vessel area density (VAD), vessel skeleton density (VSD), and vessel complexity index (VCI ...

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