1. Photodynamic opening of the blood-brain barrier and pathways of brain clearing

    Photodynamic opening of the blood-brain barrier and pathways of brain clearing

    A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; 2) using optical coherence tomography and intra-parenchymal injection of gold nanorods we observed their clearance through the exit gate of cerebral spinal fluid from ...

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