1. Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain

    Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain

    An automated serial histology setup combining optical coherence tomography (OCT) imaging with vibratome sectioning was used to image eight wild type mouse brains. The datasets resulted in thousands of volumetric tiles resolved at a voxel size of ( 4.9 × 4.9 × 6.5 ) μ m 3 (4.9×4.9×6.5)  μm3 stitched back together to give a three-dimensional map of the brain from which a template OCT brain was obtained. To assess deformation caused by tissue sectioning, reconstruction algorithms, and fixation, OCT datasets were compared to both in vivo and ex vivo magnetic resonance imaging (MRI) imaging. The OCT ...

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