1. Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

    Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

    Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (<25 yr) and 10 older (>54 yr) subjects. All young subjects and five of the older subjects had retardance values induced by the retinal pigment epithelium and Bruch's membrane (RPE-BM) complex that were just above ...

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