1. Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

    Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress

    Objectives The aim of this study was to identify the determinants of plaque structural stress (PSS) and the relationship between PSS and plaques with rupture. Background Plaque rupture is the most common cause of myocardial infarction , occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound–virtual histology studies indicate that <10% higher risk plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture. Plaque rupture occurs when PSS exceeds its mechanical strength; however, the determinants of PSS and its association with plaques with proven rupture are not known. Methods We analyzed ...

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