1. Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography

    Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography

    Background and Objective Wound healing involves a complex and dynamic biological process in response to tissue injury. Monitoring of the cascade of cellular events is useful for wound management and treatment. The aim of this study is to demonstrate the potential of multifunctional polarization-sensitive optical coherence tomography (PS-OCT) to longitudinally monitor the self-healing process in a murine cutaneous wound model. Materials and Methods A multi-functional PS-OCT system based on swept source OCT configuration (1,310 nm central wavelength) was designed to obtain simultaneously microstructural, blood perfusion, and birefringent information of a biological tissue in vivo . A 1-mm-diameter wound was generated ...

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