1. Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

    Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

    A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo , further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening.

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