1. Validation of optical coherence tomography retinal segmentation algorithm in neuro-degenerative disease

    Validation of optical coherence tomography retinal segmentation algorithm in neuro-degenerative disease

    Purpose : This study compared the automated retinal segmentation software of spectral domain optical coherence tomography (SD-OCT) with manually corrected segmentation in order to guide and validate its use in a prospective clinical study of neuro-degenerative diseases (NDD). Methods : The sample comprised 30 NDD patients, including individuals with vascular cognitive impairment (n=13), frontotemporal dementia (n=6), Parkinson's disease (n=6) and Alzheimer's disease (n=5). Retinal SD-OCT scans were acquired for both eyes and then segmented using the Heidelberg Spectralis (Heidelberg, Germany) software (version 6.3.4.0). All SD-OCT scans had a quality score of 20 or ...

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