1. Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis

    Using polarisation-sensitive optical coherence tomography and mechanical indentation to assess cartilage degeneration in the bovine model of early osteoarthritis

    Recent studies have shown potential for using polarisation sensitive optical coherence tomography (PS-OCT) to study cartilage morphology, and this presents a useful real-time non-invasive tool for detecting osteoarthritic changes. However, there has been relatively limited ability of this method to quantify the subtle changes in the early stages of joint degeneration. In this study, we investigate the ability of PS-OCT to detect microscale degenerative changes in cartilage, following compression, using a validated animal model of early cartilage degeneration, and a special indentation technique. It was found that PS-OCT was able to detect and quantify microstructural changes between healthy and early ...

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