1. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

    Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

    Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen, and cell contours, while dynamic FFOCT emphasizes metabolic activity of moving structures that are mainly intracellular, thus creating or enhancing contrast in cells that were previously hidden in noise. Dynamic ...

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