1. Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

    Combination of optical coherence tomography and near infrared spectroscopy enhances determination of articular cartilage composition and structure

    Conventional arthroscopic evaluation of articular cartilage is subjective and poorly reproducible. Therefore, implementation of quantitative diagnostic techniques, such as near infrared spectroscopy (NIRS) and optical coherence tomography (OCT), is essential. Locations ( n  = 44) with various cartilage conditions were selected from mature equine fetlock joints ( n  = 5). These locations and their surroundings were measured with NIRS and OCT ( n  = 530). As a reference, cartilage proteoglycan (PG) and collagen contents, and collagen network organization were determined using quantitative microscopy. Additionally, lesion severity visualized in OCT images was graded with an automatic algorithm according to International Cartilage Research Society (ICRS) scoring system. Artificial ...

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