1. Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

    Physical Sciences, Incorporated Receives NIH Grant  for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

    Physical Sciences, Incorporated Receives a 2017 NIH Grant for $525,207 for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins. The principal investigator is Nicusor Iftima. The program began in 2014 and end sin 2019. Below is a summary of the proposed work.

    Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment of surgical margins on breast cancer lumpectomy specimens and provide immediate feedback to the surgeon. A multimodal microscope will be used in conjunction with a high sensitivity cancer targeting agent to detect positive margins on lumpectomy specimens. Enhanced contrast fluorescence imaging will be first applied to identify potentially positive margins, while combined high-resolution confocal microscopy-optical coherence tomography imaging will be then used to visualize tissue morphology at the sub-cellular scale and confirm or rule out cancer presence. In Phase I we demonstrated the suitability of this technology for positive cancer margins detection on surgical specimens in a benchtop study. Based on Phase I observations and conclusions we propose to further improve this technology in Phase II and perform a larger scale clinical validation study at the MD Anderson Cancer Center, Houston, TX. Furthermore, a commercialization strategy for this technology will be developed and preliminary steps towards reaching this goal will be taken.

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