1. Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice

    Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice

    A multi-modality imaging-based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (OCT) (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting abdominal aortic aneurysms induced in male apolipoprotein E-null mice by high-dose angiotensin II infusion. In vivo morphological and hemodynamic data provide information on volumetric lesion growth and changes in blood ...

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