1. OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS (Thesis)

    OPTICAL COHERENCE TOMOGRAPHY TO MEASURE EFFECTS OF AUTOLOGOUS MESENCHYMAL STEM CELL TRANSPLANT IN MULTIPLE SCLEROSIS PATIENTS (Thesis)

    Anterior visual pathway disease affects >50% of multiple sclerosis (MS) patients. Optical coherence tomography (OCT) monitors MS-related retinal degeneration. Retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thinning in MS correlates with clinical and visual disability, and brain atrophy. Mesenchymal stem cells (MSC) are immunomodulatory in MS animal models, targeting inflammatory CNS injury. A recent Cleveland Clinic phase 1 trial demonstrated feasibility/tolerability of autologous MSC transplant in MS patients. My study analyzed GCL and RNFL relationships with clinical, visual, and MRI measures, before and after MSC transplant. MSC transplant affected no differences from baseline to 6 months ...

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