1. Study on laser-assisted drug delivery with optical coherence tomography

    Study on laser-assisted drug delivery with optical coherence tomography

    The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. Nail plate divided into three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. Moreover, optical coherence tomography (OCT) is implemented for real-time monitoring of the laser–skin tissue interaction, sparing the patient from invasive surgical sampling procedure. Observations of drug diffusion through the induced ...

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