1. Retinal oximetry in humans using visible-light optical coherence tomography [Invited]

    Retinal oximetry in humans using visible-light optical coherence tomography [Invited]

    We measured hemoglobin oxygen saturation (sO 2 ) in the retinal circulation in healthy humans using visible-light optical coherence tomography (vis-OCT). The measurements showed clear oxygenation differences between central retinal arteries and veins close to the optic nerve head. Spatial variations at different vascular branching levels were also revealed. In addition, we presented theoretical and experimental results to establish that noises in OCT intensity followed Rice distribution. We used this knowledge to retrieve unbiased estimation of true OCT intensity to improve the accuracy of vis-OCT oximetry, which had inherently lower signal-to-nose ratio from human eyes due to safety and comfort limitations ...

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