Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography
A customized 1310-nm Jones-matrix optical coherence tomography (JM-OCT) for dermatological investigation was constructed and used for in vivo normal human skin tissue imaging. This system can simultaneously measure the threedimensional depth-resolved local birefringence, complex-correlation based OCT angiography (OCT-A), degree-ofpolarization- uniformity (DOPU) and scattering OCT intensity. By obtaining these optical properties of tissue, the morphology, vasculature, and collagen content of skin can be deduced and visualized. Structures in the deep layers of the epithelium were observed with depth-resolved local birefringence and polarization uniformity images. These results suggest high diagnostic and investigative potential of JM-OCT for dermatology.