1. Optical Coherence Tomography (oct) A New Method For In Vivo Imaging And Quantification Of Collateral Vessel Growth In Mice

    Therapeutic augmentation of collateral vessel growth (arteriogenesis) is of particular clinical interest. Quantification of collateralization in small animal models is, however, difficult and the commonly used technique of Laser Doppler perfusion imaging (LDPI) has always been criticized, especially as determination of flow in the vascular system is infeasible. We hypothesized that the new technology of optical coherence tomography (OCT), a non-invasive high resolution tomography imaging technique, may constitute a valuable tool for in vivo imaging of the remodelling of an arteriole into a full collateral vessel in mice. The morphology of the collateral vessels in the adductor muscle was visualized ...
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