tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a detailed comparison of OCT and another modality, optical projection tomography (OPT), in murine-embryo studies. 2 Most commonly used for ophthalmological imaging, 3 OCT has proved a powerful embryonic-imaging modality as ...