1. Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery

    Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery

    Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established. The aim of this study, was to investigate the importance of time-related topical application after AFXL exposure and to relate resultant uptake in skin with AFXL channel morphology and skin integrity. Study Design/Materials and Methods Buttock skin of healthy volunteers ( n  = 11) was exposed to 10,600 nm fractional CO 2 laser using 5% density, 120 ...

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