1. Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability

    Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability

    Background To determine the impact of retinal pigment epithelium (RPE) pathology on intersession repeatability of retinal thickness and volume metrics derived from Spectralis spectral-domain optical coherence tomography (SD-OCT). Design Prospective cross-sectional single centre study. Participants 56 eyes of 56 subjects were divided into 3 groups: (A) normal RPE band (25 eyes), (B) RPE elevation: macular soft drusen (13 eyes) and (C) RPE attenuation: geographic atrophy or inherited retinal diseases (18 eyes). Methods Each subject underwent three consecutive follow-up macular raster scans (61 B-scans at 119 micron separation) at 1-month intervals. Main outcome measures Retinal thicknesses and volumes for each zone ...

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