1. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

    Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

    Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating ...

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