1. Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

    Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

    Developing a deep-tissue imaging tool with good optical resolution is one of the important goals of biophotonics because medical diagnosis usually requires imaging of fine details of whole tissue structures. Optical coherence tomography (OCT) is an extensively developed imaging tool for biological tissues. Based on low-coherence interferometry, OCT provides micrometer scale resolution and enables non-invasive high-speed imaging1 . OCT is widely used in ophthalmology because it can fully access retina, choroid and sclera layers of human eyes in vivo. 2, 3 OCT has a higher penetration depth of 12 mm compared to other optical imaging modalities such as multi-photon microscopy ...

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