1. Application of optical coherence tomography in the diagnosis of mucositis in patients with head and neck cancer during a course of radio(chemo)therapy

    Objective Mucositis is the most common oral complication of non-surgical therapy (chemotherapy, radiotherapy, and radio(chemo)therapy) in patients with head and neck cancer. Growing evidence indicates that more aggressive treatment regimens improve local tumor control and the survival of patients with locally advanced head and neck cancer. However combined therapy approaches are associated with higher acute toxicity. Currently there are no in vivo methods to visualize microscopic changes of mucosal structure during a course of radio(chemo)therapy and to assess the development and healing of oral mucositis. As a result it has been impossible to predict its severity ...
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