1. Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography

    Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography

    Purpose : To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA). Methods : Healthy participants received 6×6-mm macular and 4.5×4.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images. Background OCTA noise in static tissue was evaluated in the foveal avascular zone (FAZ). Vessel density was calculated from en face retinal OCTA that was binarized according to ...

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