1. Calibration of optical coherence tomography angiography with a microfluidic chip

    Calibration of optical coherence tomography angiography with a microfluidic chip

    A microfluidic chip with microchannels ranging from 8 to 96    μ m 96  μm was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width. SSADA could differentiate nonflowing blood inside the microfluidic channels from static paper. The SSADA decorrelation value was approximately linear with blood flow velocity up to a threshold V sat Vsat of 5.83 ± 1.33    mm / s 5.83 ...

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